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Overview
The long-term goal of the Glykys Laboratory is to identify novel strategies to treat seizures and cytotoxic edema, especially in neonates.
To reach this goal, we are addressing the following themes:
- The workings of the brain's inhibitory system at the cellular and network level.
- Movement of water and ions move in and out of neurons.
- Neuronal injury pathways after hypoxia, excitotoxic injury, and seizures.
Research areas of the lab include:
- Changes in neuronal chloride, calcium, and cellular volume during pathological conditions.
- Neonatal seizures and epilepsy.
- GABAA receptor physiology.
We approach these research areas with electrophysiological and two-photon imaging techniques in the neocortex. We complement these approaches with immunohistochemistry.
Learn more by checking these recent publications:
Suryavanshi P, Langton R, Fairhead K, Glykys J. Brief excitotoxic insults cause a calpain-mediated increase in nuclear membrane permeability in neonatal neurons. bioRxiv. 2023, Aug 23;2023.08.22.554167. doi: 10.1101/2023.08.22.554167.
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Takezawa Y, Langton R, Baule SM, Zimmerman MB, Baek J. Glykys, J. Role of NKCC1 and KCC2 during hypoxia-induced neuronal swelling in the neonatal neocortex. Neurobiol. Dis. 2023. Mar;178:106013. PMID: 36706928
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Langton R, Sharma S, Tiarks GC, Bassuk AG, Glykys, J. Lacosamide decreases neonatal seizures without increasing apoptosis. Epilepsia. 2022. Dec;63(12):3051-3065. PMID: 36168798
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Tong L, Langton R, Glykys J, Baek S. ANMAF: An automated neuronal morphology analysis framework using convolutional neural networks. Scientific Reports. 2021 April 14;11(1):8179. PMID: 33854113.
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